On a typical weekday there are 54 scheduled rail journeys between London Euston and Manchester Piccadilly, with 46 of them being direct trains. There are also a further 8 possible journeys which require a change.

The distance by rail from London Euston to Manchester Piccadilly is approximately 161 miles (259 kilometres). The average train journey takes about 2hrs 52 mins.

First TransPennine Express and London Overground and East Midlands Railway and West Midlands Trains and Transport for Wales and Avanti West Coast and CrossCountry and London North Eastern Railway and Caledonian Sleeper are the main train operating companies running services between London Euston and Manchester Piccadilly.

There are 9 possible routes with the shortest and most direct being London Euston to Manchester Piccadilly. The fastest journey time on this route takes 2hrs 6 mins.