On a typical weekday there are 55 scheduled rail journeys between Manchester Stations and London (All Stations), with 47 of them being direct trains. There are also a further 8 possible journeys which require a change.

The distance by rail from Manchester Stations to London (All Stations) is approximately 162 miles (262 kilometres). The average train journey takes about 2hrs 40 mins.

Northern Rail and First TransPennine Express and London North Eastern Railway and Transport for Wales and Avanti West Coast and CrossCountry and East Midlands Railway are the main train operating companies running services between Manchester Stations and London (All Stations).

There are 8 possible routes with the shortest and most direct being Manchester Piccadilly to London Euston. The fastest journey time on this route takes 2hrs 6 mins.